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BIOQUAL Inc
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Applied StemCell Inc
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Innovive Inc
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Image Search Results
Journal: Cancer Research
Article Title: Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
doi: 10.1158/0008-5472.can-21-0732
Figure Lengend Snippet: Figure 5. Combination effects of ceritinib and olaparib in HGSOC PDX models. A–E, SCID beige mice were inoculated by intraperitoneal injection of disaggregated PDX tumors, with indicated gene alterations and HRD scores. When tumors reached 0.3–0.5 cm2 in cross-sectional area by transabdominal ultrasound, mice were treated daily by oral gavagewith 100 mg/kg ceritinib,50 mg/kg olaparib,or100 mg/kg ceritinib þ50 mg/kg olaparib for 9weeks or until tumor dimensions determined byultrasound indicated that tumors were greater than or equal to 10% of body weight or if humane endpoints were met. Tumor areas were monitored weekly by transabdominal ultrasound. Coloring in the plot indicates drug arm. Predicted lines are the average estimates computed from the statistical model fixed effects, relative to the arm- specific baseline estimate. Shading indicates 95% confidence intervals. The P values are provided in Supplementary Table S3. The number of mice under observation at each time point for each arm is indicated below the x-axis as a function of time, where text color indicates drug arm.
Article Snippet: Tumors were established by intraperitoneal injection into female
Techniques: Injection
Journal: Asaio Journal
Article Title: The Current Status of Bioartificial Pancreas Devices
doi: 10.1097/MAT.0000000000001252
Figure Lengend Snippet: Summary of Results from Device Preclinical and Clinical Testing.
Article Snippet:
Techniques: Animal Model, Derivative Assay, In Vitro, In Vivo, Diffusion-based Assay, Transplantation Assay